ALICE detects the bacteria causing chronic endometritis to improve your patient's reproductive outcome
Independent studies show that this condition affects up to 30% of infertile patients, and in cases of repeated implantation failure or recurrent pregnancy loss, this can rise to 66%*.
According to our scientific publication ’The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology’, ALICE method is similar in reliability to the three classic diagnostic methods.
Moreno et al. Am J Obstet Gynecol. 2018, DOI: 10.1016/j.ajog.2018.02.012.
ALICE can be performed on a small piece of endometrial biopsy.
If the patient is undergoing an ERA test, a small portion of the same biopsy can be used, so no additional sample will be required.
ALICE can be beneficial for any patient wishing to conceive, by assessing the microbiological environment that the embryo will encounter at implantation.
ALICE may also be beneficial for patients with a history of recurrent pregnancy loss or recurrent implantation failure because chronic endometritis has been linked to these events.
ALICE uses the latest Next Generation Sequencing technology to provide microbiome information in endometrial tissue by analyzing the abundance of specific bacteria causing chronic endometritis.
The data obtained from analysing more than 12,000 samples with ERA was used to develop this new predictor.
This enables us to define more clearly each one of the endometrial profiles and their subcategories in relation to the clinical objective of pregnancy and the birth of a child.
Meanwhile, the degree of flexibility in the analyses with NGS technology is a lot higher. This enables the addition of extra tests, such as the endometrial microbiome, which will soon be performed on the same sample, in turn supplementing and improving the data obtained from the ERA test.
Mahajan N.
J Hum Reprod Sci.2015 Jul-Sep;8(3):121-9. doi: 10.4103/0974-1208.165153. PMID: 26538853 [PubMed] PMCID: PMC4601169. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/26538853
Gómez E, Ruíz-Alonso M, Miravet J, Simón C.
Cold Spring Harb Perspect Med. 2015 Mar 27. pii: a022996. doi: 10.1101/cshperspect.a022996. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/?term=Human+Endometrial+Transcriptomics%3A+Implications+for+Embryonic+Implantation
Ruiz-Alonso M, Blesa D, Simón C.
Biochim Biophys Acta. 2012 Dec;1822(12):1931-42.
http://www.ncbi.nlm.nih.gov/pubmed/22634130
Garrido-Gómez T, Ruiz-Alonso M, Blesa D, Diaz-Gimeno P, Vilella F, Simón C.
Fertil Steril. 2013 Mar 15;99(4):1078-85.
http://www.ncbi.nlm.nih.gov/pubmed/23312228
Bermejo A, Cerrillo M, Ruiz-Alonso M, Blesa D, Simón C, Pellicer A, Garcia-Velasco JA.
Fertil Steril. 2014 Jan;101(1):138-146.e3.
http://www.ncbi.nlm.nih.gov/pubmed/24182413
Bermejo A, Iglesias C, Ruiz-Alonso M, Blesa D, Simón C, Pellicer A, García-Velasco J.
Hum Reprod. 2014 Jun;29(6):1271-8. doi: 10.1093/humrep/deu065. Epub 2014 Apr 4.
http://www.ncbi.nlm.nih.gov/pubmed/24706003
Blesa D, Ruiz-Alonso M, Simón C.
Semin Reprod Med. 2014 Sep;32(5):410-3. doi: 10.1055/s-0034-1376360. Epub 2014 Jun 24.
http://www.ncbi.nlm.nih.gov/pubmed/24959823
Díaz-Gimeno P, Ruíz-Alonso M, Blesa D, Simón C.
Int J Dev Biol. 2014;58(2-4):127-37. doi: 10.1387/ijdb.130340pd.
http://www.ncbi.nlm.nih.gov/pubmed/25023678
Nejat EJ, Ruiz-Alonso M, Simón C, Meier UT.
Fertil Steril. 2014 Sep 17. pii: S0015-0282(14)02025-1. doi: 10.1016/j.fertnstert.2014.07.1254.
http://www.ncbi.nlm.nih.gov/pubmed/25241377
Hum Reprod. 2014 Sep;29(9):1957-67. doi: 10.1093/humrep/deu171. Epub 2014 Aug 8
http://www.ncbi.nlm.nih.gov/pubmed/25106620
Our reliable and approachable team of experts is ready to guide clinicians and patients throughout the entire process. We are proud to deliver high quality results for every test, every day.
of infertility is caused by
the endometrial factor
of infertile women
have pathogenic
bacteria
years' experience
in genetics
laboratories worldwide
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