SAT - Middle East

Overview

SAT
Benefits
Indications

What is SAT test?

- The Sperm Aneuploidy Test (SAT) is a test to study the genetic factor of male infertility.
- It allows for the evaluation of the presence of an abnormal number of chromosomes (aneuploidy and diploidy) in the sperm.
- The chromosomes 13, 18, 21, X and Y, are most frequently implicated in spontaneous miscarriages and affected offspring with chromosomal abnormalities. In SAT, these chromosomes are analysed by fluorescence in situ hybridization (FISH).

What is the procedure?

Why should use SAT test?

An increase of sperm chromosomal abnormalities affects your reproductive journey at three levels:

EMBRYO LEVEL:

- - Spermatozoa with sex chromosome abnormalities results in aneuploid embryos
  - Diploid sperm results in triploid embryos

Rodrigo et al., 2010.

PREGNANCY LEVEL:

- - An altered SAT decreases pregnancy rate after ICSI and increases miscarriage rate

Rubio et al., 2001.

OFFSPRING LEVEL:

- - Sperm chromosomal abnormalities increase the risk of abnormal offspring for the chromosomes affected in the sperm (Down, Klinefelter or Turner’s Syndromes)

Who should use SAT test?

- - Men with a low sperm concentration, who typically have a higher incidence of sperm chromosome abnormalities
  - Couples who have suffered recurrent miscarriage of unknown origin
  - Couples who have experienced repeated implantation failure
  - Couples with a previous pregnancy with a chromosomal abnormality

Test limitations

- - This technique allows the detection of aneuploidy only for the chromosomes included in the test (13, 18, 21, X and Y).
  - In very few ejaculated samples or testicular samples, there is not enough spermatozoa for a proper estimation of the risk of aneuploidy.

SAT Specialists’ documents

Clinical Sheets

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Scientific evidence

Relevant related studies:

Rodrigo L, Peinado V, Mateu E, Remohí J, Pellicer A, Simón C, Gil-Salom M, Rubio C. Impact of different patterns of sperm chromosomal abnormalities on the chromosomal constitution of preimplantation embryos. Fertil Steril. 2010 Sep; 94(4):1380-6.

Rubio C, Gil-Salom M, Simón C, Vidal F, Rodrigo L, Mínguez Y, Remohí J, Pellicer A. Incidence of sperm chromosomal abnormalities in a risk population: relationship with sperm quality and ICSI outcome. Hum Reprod. 2001 Oct; 16(10):2084-92.

Rodrigo L, Mateu E, Mercader A, Cobo A, Peinado V, Milán M, Al-Asmar N, Campos-Galindo I, García-Herrero S, Mir P, Simón C, Rubio C. New tools for embryo selection: comprehensive chromosome screening by array comparative genomic hybridization. BioMed
Research International. 2014; In Press.

Igenomix and fertility

We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility doctors worldwide we investigate human reproduction to change the lives of couples who are trying to conceive.

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Up to 60% of pregnancies miscarry due to sperm chromosomal abnormalities

Results in two weeks

SAT provides personalized genetic counseling to the infertile couple before an IVF treatment

2,000 spermatozoon analyzed for each chromosome

Are You interested?

Overview

What is SAT test?

What is the procedure?

Why should use SAT test?

Who should use SAT test?

Test limitations

Clinical Sheets

Scientific evidence

Relevant related studies:

Can we help you?

Igenomix and fertility

PGT-A

ERA

EndomeTRIO

SAT Sperm aneuploidy test

Analysis of chromosomal abnormalities in sperm

Up to 60% of pregnancies miscarry due to sperm chromosomal abnormalities

Results in two weeks

SAT provides personalized genetic counseling to the infertile couple before an IVF treatment

2,000 spermatozoon analyzed for each chromosome

Are You interested?

Overview

What is SAT test?

What is the procedure?

Why should use SAT test?

Who should use SAT test?

Test limitations

Clinical Sheets

Scientific evidence

Relevant related studies:

Can we help you?

Igenomix and fertility

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ERA

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Igenomix is in the media