ERA® Endometrial Receptivity Analysis

The ERA® test helps avoid implantation failure by establishing the best day for embryo transfer

Overview

Many women undergoing IVF are unable to get pregnant, even after transferring good quality embryos. Although a good quality embryo it’s an important starting point, it is also important to transfer the embryo into a uterus that is ready to receive the embryo.
The timing of embryo transfer must be coordinate with your body´s menstrual cycle, neither too early nor too late, but at just the right time. For most women, the best time to transfer an embryo it´s the same, but for some women, it can be different.

What is the endometrium?

The interior of the uterus is lined with a tissue called endometrium, which is prepared each month for the arrival of an embryo and it’s the nest where the embryo implants and resides during gestation. Even the best embryo will fail to implant if conditions aren’t right.

What is Endometrial receptivity?

The endometrium is receptive when it is ready for embryo implantation to occur. This period of receptivity is called the window of implantation.

Each woman has a unique window. For some women the window is shorter and/or displaced. By knowing your personal window of implantation, you can optimise your chances of pregnancy through a personalised embryo transfer.

What is ERA test?

Using a small sample of endometrial tissue the ERA test establishes the best day for transferring the embryo.
ERA will determine if the endometrium is receptive or not at the time of sampling, by analysing 248 genes involved in endometrial receptivity.
ERA testing can find your personalized WOI in case of displacement, and will allow a personalized embryo transfer (pET).

*Simón et al., In vitro fertilization with personalized blastocyst transfer versus frozen or fresh blastocyst transfer: a multicenter, randomized clinical trial. Fertility and Sterility, 2019; 112. e56-e57. 10.1016/j.fertnstert.2019.07.273.**Oral presentation, Clemente-Císcar, ESRHE 2018.

Is ERA for you?

This test is recommended if:

You have suffered an implantation failure.
You are undergoing assisted reproduction treatment.

ERA test results

A RECEPTIVE RESULT

A receptive result shows that the window of implantation is ‘open’ at the time and day of taking the sample and the recommendation is to proceed with embryo transfer under the same conditions as the biopsy.
A NON – RECEPTIVE RESULT

A non-receptive result shows a displaced window of implantation. In this case, with the ERA computational predictor, we will estimate your window of implantation and indicate the optimal time for your personalised embryo transfer.

Why use ERA?

When performing a personalised embryo transfer, the likelihood of getting pregnant in assisted reproduction treatment is increased
72.5%* pregnancy rate using ERA in the first IVF cycle in any patient.

*Ruiz-Alonso et al, Fertil Steril. 2013. Clemente-Ciscar et al, 2018, submitted

How does it work?

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72.5%*pregnancy rate using ERA in the first IVF cycle in any patient

Even the best embryo will fail to implant if conditions aren’t right

3 in every 10 women have a displaced window of implantation**

Overview

What is the endometrium?

What is Endometrial receptivity?

What is ERA test?

Features

Is ERA for you?

ERA test results

A RECEPTIVE RESULT

A NON – RECEPTIVE RESULT

Why use ERA?

BROCHURE

Request for Genetic counseling Session

Do you have any questions?

EMMA

ALICE

EndomeTRIO